00:00but the time you view this it's likely to be much later but while I'm taping this it's January at 30th 2019 and there's a life-threatening arctic blast surging into the Midwest and I'm in Lexington Kentucky and it seems to have hit here already we had a little bit of snow actually I woke up to snow scraping this morning at 5:30 which is unusual for us and when you look out there there's not that much snow but why did I start off with that the topic here is supposed to be heat shock proteins well it's interesting timing I've been watching a few videos on heat shock proteins I went a little bit deeper and learned a little bit more about those where did those videos come from Rhonda Patrick I know many of you many of my viewers also watched dr. Patrick there was a fellow I think it was Peter that
01:00said you might look at a version you might want to check out dr. Patrick Peter was talking actually about the the interview with such an panda I've seen that again recently and actually want to do an update on on time restricted eating there was I covered the the article by dr. panda and Valter Longo but wanted to go into some more depth anyway the bottom line is I'm a major fan of dr. Patrick someone else mentioned that she was a prodigy of dr. Bruce Ames if you haven't heard of Bruce Ames I did a video on him as well he's one of the the major heavy hitters on nutrition focused on micronutrients he did the the triage theory of micronutrients and again I did a video on that he also was credited by many for
02:00it he might Accountant mitochondrial theory of aging he he also had a lot to do with the recent discoveries of k2 so he's a significant force in nutrition and again dr. Patrick's a mentor-mentee of his now back to heat shock proteins I'm going to cover a few items the Wikipedia section on heat shock proteins is very very interesting and I'm going to use that a little bit later to talk about some of the details associated with heat shock proteins but first let's talk about why we went there it had to do with this dr. Patrick was talking in and then a couple of interviews one with Joe Rogan and I think another with oh gosh can't
03:00remember the name right now but she was talking about extremes of temperature and specifically heat her point was look when I was going through my stressful training with dr. Bruce Ames one of the things that really kept me sane was saunas she went on to talk about heat stress it has been shown to improve endurance and athletes prevent atrophy during muscle lack of muscle use improve insulin sensitivity increased bone dry nature addict factor and norepinephrine again I'll get into those details right now and appears to be associated with longevity she went on to talk about Fox o3 some other things but why here's why back in 2015 there was an article published by a doctor Lacan --an and evidently someone else in his family jerry Lacan inand I guess Tanjong Neela may have been as his wife I don't know but they looked at their couple of fence
04:00Finnish researchers that looked at sauna bathing and they found an incredibly powerful association with health I'll go a little bit deeper into that article later because I think it it's sort of like the the review of doctor diamonds work I agree with about 95 maybe 98% of what I've seen so far except I have am withholding a little bit of skepticism regarding this article and we'll talk about that in another video but before we do let's just go back and review some of the things that we find with heat shock proteins I will
05:00say that there's been some research done more recently there does appear to be an independent association but again that's for another video at another time let's talk about heat shock proteins and why they're interesting so there are family of proteins that are produced by cells in response to stressful conditions and so one of the things that they found after finding this category of proteins researchers obviously thought the next thing well what about other stressors including cold UV light etc and sure enough some of the same proteins are created and some related proteins are created so it makes you wonder well if all of these things are really that healthy for you why do we not see a significant
06:00improvement in longevity in people that are that are doing things like wim HOF with the cold exposure or maybe saunas I guess one of the questions I would have is how do we know that we're not seeing that I don't think that we do know that yet if you're confused about the epidemiology around all cause mortality and lifespan I did another video on that as well the bottom line is if you're there are so many different causes of death and causes of shortening our lifespan that if we look at one it may be very important for example Sona may be very important you may or may not see an impact on all cause mortality again just because there's so many different ways of dying but let's get back to heat shock proteins as I
07:00mentioned in the title and I haven't gotten there yet heat shock proteins are very much related to Auto Fiji and other immune functions now why is that part of it has to do with this term chaperone chaperones are proteins that assist the covalent folding or unfolding or the assembly or disassembly of macromolecular structures or even other proteins so the point and we'll show some pictures on that in just a minute when a new protein is is being developed it has to fold correctly in order to have the right geometry sometimes it needs help and that's what heat shock proteins tend to do now if heat shock proteins are involved in helping hold protein other proteins and amino acid
08:00chains or peptides in certain geometric space then they also have other roles as well and we'll talk about those again in just a minute now there's a thing called heat shock factor heat shock factors are the transcription factors that regulate the expression of heat shock proteins in other words let's say you do go to the sauna let's say you do start stimulating your body to create heat shock proteins well it's heat shock factors that start this process that began to begin that transcription process it's seen in bacteria it's seen in humans it's seen in virtually all living organisms here's one version of one this is heat shock protein number as you can see there are six major families the 40s 60s 70s 90s and one
09:00tense those are the Daltons or the molecular weight of these as you can see it's almost appears to be like a a ring and again that may be something like a handcuff that's used to guide and direct the geometry of the protein there are others as well again very much focused on geometric the holding of a protein in the correct geometric space now what about cardiovascular there has been a significant amount of cardiovascular focus on these and again I'll cover that in another probably two maybe three videos on the Jama articles and that debate that they tripped off just a brief comment about it if you look at the actual dose response curve and we'll talk about a dose response
10:00curve later the cardiovascular impact would if it were true and as large as was demonstrated in the in the 2015 JAMA internal medicine article going to the sauna would be maybe more important than losing weight maybe I'm more important than exercise just incredibly important and again as I've mentioned I'm a little bit I think that there is a significant component here but I'm skeptical that it's as big as it appeared to be in that gem article and again we'll talk about why later in a different article now so immunity as as I've meant we mentioned a couple of times heat shock proteins are important to aligning the again geometric shape of a protein well that's
11:00also used in in presentation we'll talk about that actually right now antigen presentation now when something comes into the body like a virus there are several steps for the that the body has to go through in order to recognize that virus shell as an antigen or foreign one is a thing called oh gosh there's a name of a cell I think we'll cover that a little bit later but there's a specific type of immune cell antigen presenting cell that's the name of it I think and then that antigen presenting cell has a role of presenting the portion of the virus the portion of the virus shell
12:00to the T cells when the T cells are presented that peptide from the virus shell in a certain way by the antigen presenting cell they recognize that as foreign and again as we've talked about in several other videos there's a lot of places where that doesn't exactly happen correctly like with rheumatoid arthritis some of the inflammatory bowel diseases and there's something that's going on as we all know with cardiovascular inflammation where the immune system is attacking our own plaque within the walls of our arteries but again I'm going down some bunny trails let's go back and continue the discussion about heat shock proteins so heat shock proteins are because of their focus with
13:00the geometry and presentation of the protein they are very much associated with these antigen presenting cells or presentation cells so again they get involved in helping present this in turn to the antigen presenting cell which presents it to the t-cell so the t-cell can recognize it as something that's foreign and therefore needs to be attacked so let's go go on down now what does that have to do with autophagy I mentioned that's half a G in the title and went through a lot of other dots to connect before I finally get here and here there's only two lines about etapa G but think about it autophagy is a place where we recognize
14:00our cells recognize junk protein for the most part but other pieces of junk as well that protein is then presented to the lysosome in the lysosome is a packet of proteins which is ready to be digested and dissolved so again heat shock proteins are not only involved in helping present other protein help other proteins form when the other when those other proteins get denatured by heat or other stressors they help them reform denature just means that the geometric form has been has been changed so for example some of you may remember the picture that I showed in the thumbnail of a recent video of fried eggs when you
15:00fry eggs basically your denaturing the protein in the egg heat shock proteins because of their role can come back and renature or renature or reconfigure proteins now sometimes obviously with a fried egg they couldn't remake a a nun fried egg and at that point then if the protein is that destroyed then they will go ahead and present it to a lysosome if that's a protein that they that appears to be from a viral infection again they're involved in presenting it to the antigen presentation cells so again there's a lot more interesting stuff about heat shock proteins and cold shock proteins and UV shock proteins and several others but again we're getting on I appreciate your interest as usual if you've made it this far and gotten
16:00this this geeky with me thanks for your interest